Gonadorelin (GnRH)
Price on application
Gonadorelin is a synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH). It stimulates the anterior pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), playing a central role in reproductive endocrinology.
Research Profile
Gonadorelin is the synthetic form of the hypothalamic decapeptide GnRH (also known as LHRH). When administered in a pulsatile fashion mimicking natural secretion, it stimulates the anterior pituitary gonadotroph cells to synthesize and release both LH and FSH. This makes it an essential research tool for studying the hypothalamic-pituitary-gonadal (HPG) axis and for applications in fertility research, hormone restoration protocols, and diagnostic endocrinology. Continuous (non-pulsatile) administration produces an opposite effect — downregulation of GnRH receptors and suppression of gonadotropin release. Gonadorelin has FDA-approved diagnostic applications for assessing pituitary gonadotroph function.
Technical Details
- Chemical Formula
- C55H75N17O13
- Synonyms
- GnRH, LHRH, Luteinizing Hormone-Releasing Hormone, Factrel
- Molecular Weight
- 1182.29 g/mol
- CAS Number
- 33515-09-2
- PubChem ID
- 638793
- Sequence
- pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
- Appearance
- Lyophilized White Powder
- Purity
- >98% (HPLC Verified)
- Shelf Life
- 36 months (Store at -20°C)