Humanin
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Humanin is a 24-amino acid mitochondrial-derived peptide with potent cytoprotective and neuroprotective properties. It was discovered through its ability to suppress neuronal cell death induced by Alzheimer's disease-related genes.
Research Profile
Humanin was first identified in 2001 from a cDNA library of the occipital lobe of an Alzheimer's disease patient as a factor that suppressed cell death induced by multiple familial AD-linked genes. This 24-amino acid peptide is encoded in the 16S rRNA region of mitochondrial DNA. Humanin signals through multiple pathways: it binds to IGFBP-3 to modulate IGF signaling, activates the STAT3 pathway through the trimeric CNTFR/WSX-1/gp130 receptor complex, and interacts with BAX to inhibit apoptosis. Humanin and its analogs have demonstrated protective effects against Alzheimer's, type 2 diabetes, atherosclerosis, and ischemia-reperfusion injury. It represents a key compound in mitochondrial biology and neuroprotection research.
Technical Details
- Synonyms
- Humanin, HN, HNG (S14G Humanin analog)
- Molecular Weight
- 2687.1 g/mol
- Sequence
- Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
- Appearance
- Lyophilized White Powder
- Purity
- >95% (HPLC Verified)
- Shelf Life
- 24 months (Store at -20°C)