IGF-1 DES
Price on application
IGF-1 DES is a truncated 67-amino acid form of IGF-1 missing the first three N-terminal amino acids. This modification eliminates IGFBP binding, making it the most bioavailable and potent form of IGF-1 available for research.
Research Profile
IGF-1 DES (Des(1-3) IGF-1) is a naturally occurring truncated variant of IGF-1 that lacks the N-terminal tripeptide Gly-Pro-Glu. This structural modification virtually eliminates binding to all six IGF binding proteins (IGFBP-1 through IGFBP-6), resulting in a peptide that is approximately 10 times more potent than native IGF-1 at the receptor level. IGF-1 DES has a very short half-life of approximately 20-30 minutes, making it particularly suitable for localized research applications. It activates the IGF-1 receptor to promote cell proliferation, muscle hypertrophy, and tissue repair through PI3K/Akt and MAPK signaling cascades.
Technical Details
- Chemical Formula
- C319H501N91O96S7
- Synonyms
- Des(1-3) IGF-1, IGF-1 DES 1-3
- Molecular Weight
- 7371.4 g/mol
- CAS Number
- 112603-35-7
- Appearance
- Lyophilized White Powder
- Purity
- >98% (HPLC Verified)
- Shelf Life
- 24 months (Store at -20°C)