Kisspeptin-10
Price on application
Kisspeptin-10 is a truncated C-terminal decapeptide of the kisspeptin family that activates the GPR54/KISS1R receptor. It is a master upstream regulator of the HPG axis, directly controlling GnRH neuron firing and gonadotropin release.
Research Profile
Kisspeptin-10 is the minimal bioactive fragment of the kisspeptin family (derived from the KISS1 gene product) that retains full agonist activity at the KISS1 receptor (GPR54). Kisspeptins are essential gatekeepers of reproductive function — they directly stimulate GnRH neurons in the hypothalamus, which in turn triggers LH and FSH release from the pituitary. Kisspeptin-10 has been used in clinical research to assess HPG axis function, stimulate ovulation, and study pubertal development. Loss-of-function mutations in the KISS1R gene cause hypogonadotropic hypogonadism, underscoring the peptide's critical role. Research applications span reproductive endocrinology, fertility, and neuroendocrine physiology.
Technical Details
- Chemical Formula
- C63H83N17O14
- Synonyms
- Kisspeptin-10, Metastin (45-54), KP-10
- Molecular Weight
- 1302.44 g/mol
- CAS Number
- 374675-21-5
- Sequence
- Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
- Appearance
- Lyophilized White Powder
- Purity
- >98% (HPLC Verified)
- Shelf Life
- 36 months (Store at -20°C)