LL-37
Price on application
LL-37 is the only human cathelicidin antimicrobial peptide. This 37-amino acid peptide plays a critical role in innate immunity, exhibiting broad-spectrum antimicrobial activity, immunomodulation, and wound healing properties.
Research Profile
LL-37 is derived from the C-terminal cleavage of the precursor protein hCAP-18 (human cationic antimicrobial protein 18 kDa). It is expressed by epithelial cells, neutrophils, macrophages, and other immune cells at sites of inflammation and infection. LL-37 exerts direct antimicrobial activity against bacteria, fungi, and enveloped viruses through membrane disruption. Beyond its antimicrobial role, LL-37 functions as an immune modulator — it recruits immune cells via chemotaxis, promotes angiogenesis, stimulates wound healing, and modulates the adaptive immune response. LL-37 dysregulation has been implicated in psoriasis, rosacea, atherosclerosis, and cancer, making it a critical research compound in immunology and dermatology.
Technical Details
- Chemical Formula
- C205H340N60O53
- Synonyms
- LL-37, Human Cathelicidin, hCAP-18 (134-170)
- Molecular Weight
- 4493.33 g/mol
- CAS Number
- 154947-66-7
- Appearance
- Lyophilized White Powder
- Purity
- >95% (HPLC Verified)
- Shelf Life
- 24 months (Store at -20°C)