MGF (Mechano Growth Factor)
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MGF is a splice variant of IGF-1 produced locally in muscle tissue in response to mechanical stress. It activates satellite cells and initiates muscle repair, making it a key research compound for understanding exercise-induced hypertrophy.
Research Profile
Mechano Growth Factor (MGF) is a splice variant of the IGF-1 gene (IGF-1Ec in humans) that is expressed in skeletal muscle following mechanical overload or damage. Unlike systemic IGF-1, MGF acts locally to activate quiescent satellite cells — the muscle stem cells responsible for post-exercise repair and hypertrophy. MGF expression is one of the earliest molecular responses to muscle stretch or eccentric exercise, preceding the upregulation of other IGF-1 isoforms. Its C-terminal E-domain peptide is unique and responsible for its satellite cell-activating properties. Research applications focus on muscle repair, exercise physiology, age-related sarcopenia, and regenerative medicine.
Technical Details
- Chemical Formula
- C121H200N42O39
- Synonyms
- MGF, Mechano Growth Factor, IGF-1Ec
- Molecular Weight
- 2867.3 g/mol
- Appearance
- Lyophilized White Powder
- Purity
- >97% (HPLC Verified)
- Shelf Life
- 24 months (Store at -20°C)