RAD-140

Research Profile

Testolone (RAD-140) is an orally active, non-steroidal Selective Androgen Receptor Modulator (SARM) that binds selectively to androgen receptors (AR) in skeletal muscle and bone tissue. By mimicking the action of endogenous testosterone, RAD-140 activates anabolic signaling pathways that promote protein synthesis, muscle hypertrophy, and increased strength, while exhibiting minimal androgenic effects in non-target tissues such as the prostate and liver. RAD-140 has been shown to support bone density, enhance recovery from muscle stress or injury, and improve overall body composition by favoring lean mass accumulation over fat gain. Mechanistically, RAD-140 modulates transcriptional activity in target cells, influencing gene expression related to growth, repair, and metabolic regulation. Some studies suggest RAD-140 may interact with androgen receptors in the central nervous system, offering potential neuroprotective effects.