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SR-9011 is a second-generation Rev-ErbA agonist with improved potency and pharmacokinetic properties compared to SR-9009. It modulates circadian gene expression and enhances metabolic activity in muscle and adipose tissue.
Research Profile
SR-9011 was developed as an optimized analog of SR-9009 with enhanced Rev-ErbA binding affinity and improved oral bioavailability. In preclinical studies, it demonstrated potent effects on circadian gene regulation, leading to increased energy expenditure, reduced fat storage, and enhanced exercise capacity. SR-9011 has also shown anti-inflammatory properties by modulating macrophage activity through circadian rhythm pathways. Its improved pharmacological profile makes it a preferred tool for research into metabolic syndrome, obesity, and circadian-related metabolic disorders.
Technical Details
- Chemical Formula
- C23H31ClN4O3S
- Synonyms
- SR-9011
- Molecular Weight
- 479.04 g/mol
- CAS Number
- 1379686-29-9
- Active Ingredient
- 700mg (20mg per capsule)
- Shelf Life
- 36 months