SS-31 (Elamipretide)
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SS-31 (Elamipretide) is a mitochondria-targeted tetrapeptide that selectively concentrates in the inner mitochondrial membrane. It stabilizes cardiolipin, optimizes electron transport chain function, and reduces mitochondrial ROS production.
Research Profile
SS-31 (D-Arg-Dmt-Lys-Phe-NH2, where Dmt = 2',6'-dimethyltyrosine) is a cell-permeable, mitochondria-targeted peptide developed by Dr. Hazel Szeto at Weill Cornell Medicine. Its alternating aromatic-cationic motif enables it to traverse cell membranes and concentrate 1000-5000 fold in the inner mitochondrial membrane, where it selectively binds to cardiolipin. By stabilizing cardiolipin-cytochrome c interactions, SS-31 optimizes electron transport chain efficiency, reduces electron leak, and decreases reactive oxygen species (ROS) production. It has shown efficacy in preclinical and clinical studies for heart failure, renal ischemia, age-related mitochondrial dysfunction, and neurodegenerative diseases. Elamipretide has received FDA Orphan Drug designation for Barth syndrome.
Technical Details
- Chemical Formula
- C32H49N5O5
- Synonyms
- Elamipretide, SS-31, Bendavia, MTP-131
- Molecular Weight
- 583.77 g/mol
- CAS Number
- 736992-21-5
- Sequence
- D-Arg-Dmt-Lys-Phe-NH2
- Appearance
- Lyophilized White Powder
- Purity
- >98% (HPLC Verified)
- Shelf Life
- 36 months (Store at -20°C)