VIP (Vasoactive Intestinal Peptide)
Price on application
VIP is a 28-amino acid neuropeptide that functions as a vasodilator, immunomodulator, and neurotransmitter. It regulates smooth muscle relaxation, exocrine secretion, and circadian rhythm, with broad research applications across multiple organ systems.
Research Profile
Vasoactive Intestinal Peptide (VIP) belongs to the glucagon/secretin superfamily and is widely distributed throughout the central and peripheral nervous systems, the gastrointestinal tract, and immune cells. VIP signals through two G-protein coupled receptors: VPAC1 and VPAC2, activating adenylyl cyclase and increasing intracellular cAMP. Its physiological roles include vasodilation, bronchodilation, stimulation of pancreatic and intestinal secretions, regulation of circadian rhythms via the suprachiasmatic nucleus, and potent anti-inflammatory and immunomodulatory effects. VIP inhibits pro-inflammatory cytokine production, promotes regulatory T-cell differentiation, and protects neurons from excitotoxic damage. Research applications span gastroenterology, immunology, neuroscience, and pulmonary medicine.
Technical Details
- Chemical Formula
- C147H237N43O43S
- Synonyms
- VIP, Vasoactive Intestinal Polypeptide
- Molecular Weight
- 3326.8 g/mol
- CAS Number
- 37221-79-7
- PubChem ID
- 16129672
- Sequence
- His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
- Appearance
- Lyophilized White Powder
- Purity
- >98% (HPLC Verified)
- Shelf Life
- 24 months (Store at -20°C)