YK-11

Research Profile

YK11 (Myostatin Inhibitor / Steroidal SARM) is a synthetic steroidal selective androgen receptor modulator (SARM) that distinguishes itself from other members of the class through its dual mode of action. Unlike typical SARMs that primarily exert anabolic effects via selective androgen receptor binding, YK11 has been shown to induce the expression of follistatin, a glycoprotein that functions as a potent myostatin antagonist. By antagonizing myostatin (a negative regulator of skeletal muscle growth), YK11 potentially unlocks supraphysiological muscle hypertrophy beyond the limits imposed by endogenous regulatory pathways. Preclinical studies suggest YK11 may influence key signaling cascades such as the Smad pathway, which is central to myostatin's inhibitory effects on muscle cells. By disrupting Smad-dependent transcription, YK11 enhances myogenic differentiation and proliferation of muscle satellite cells, thereby augmenting tissue regeneration and anabolic signaling.